UVM Innovations - All Technologies

Title	Inventors (Sort Names)	Case # (Sort #s)	Description	Podcasts
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Title	Inventors	Case #	Description
Inhibitors of transitions & biofilms cause yeast cells to lose virulence	Johnson	176	Small molecules may be used to treat yeast infections and added to medical supplies to prevent biofilm formation.
Ultrafine particle detector allows in-situ engine exhaust monitoring	Frolik Holmen Barrett	402	Inexpensive detectors allow on-board monitoring of ultrafine exhaust particles that adversely affect human health.This configuration (402) offers greater portability and lower power requirements.
Sound processing improves audibility of music/speech in fMRI	Mantegna Naylor	404	Acoustic analysis and equalization mitigate fRMI noise without requiring special hardware.
Aeroacoustic cleaner removes dust from delicate surfaces	Marshall	396	A dust removal device combines acoustic levitation with aerodynamic flow to clean delicate surfaces without touching them.
Ultrafine particle detector allows in-situ engine exhaust monitoring	Frolik Holmen Barrett	389	Inexpensive detectors allow on-board monitoring of ultrafine exhaust particles that adversely affect human health.This configuration (389) also offers chemical analysis.
Whey-based wood adhesive offers environmental benefits	Guo	371	Wood glue incorporates whey, a sustainable biomass resource. The product meets or exceeds strength and durability standards for structural use.
Blood test offers early risk assessment for heart attack	Mann	317	Blood plasma assay for patients with stable coronary artery disease determines risk of developing acute coronary syndrome.
Small, multipurpose transducer is stable and responsive	Gianetti	274	Small transducer with high signal output can be adapted to numerous research applications that require measurement of 0-10 gram forces.
Wastewater treatment system offers effective, low-cost phosphorus removal	Drizo	252	An inexpensive wastewater treatment system removes up to 95 percent of phosphorus from effluent.
Dairy by-product makes fungal pest management cost-effective	Costa	250	Sweet whey makes fungal control of environmental pests cost-effective by increasing the number of spores as much as 100-fold.
Genetic approach prevents mastitis, animal agriculture's most costly disease	Bramley Plaut Kerr	97	Transgenic cows that secrete lysostaphin are highly resistant to mastitis, while traditional approaches have yielded less than 15 percent success rates.
Snowpack monitoring system improves water resource planning	Skalka Frolik	366	Snowpack monitoring system uses small, wireless sensors and offers high spatial and temporal resolution, low cost, and resistance to local influences.
Mobile app supports expert avalanche risk assessment	Skalka	367	The Stabilitron, a software tool for mobile devices, brings expert-level avalanche decision support to researchers and recreational users.
Noninvasive pulmonary airway resistance measurement system	Bates	168	Unrestrained video-assisted plethysmography provides high-throughput, non-destructive monitoring of airway resistance changes in mice.
Disposable fiber optic TIR launching system	Kennedy Warshaw	210	Disposable TIRFM slide eliminates the need for costly optics and can be used on virtually any microscope.
Immunoassays achieve highest level of sensitivity to blood FVIII levels	Parhami-Seren	192	Assay detects FVIII concentrations significantly below 1% normal physiological concentration & can quantify FVIII in healthy individuals, hemophilia patients, & patients with anti-coagulant antibodies in whom APTT cannot be used.
Diagnostic tool detects glutathionylated proteins	Janssen-Heininger	231	Method for detection of glutathionylated proteins determines their spatial location & concentration in intact cells & tissues. This may be used as a diagnostic tool or to evaluate the effectiveness of NO-delivery strategies.
Monoclonal antibodies for MCJ detection	Rincon	257	Three monoclonal antibodies detect the loss of expression of the methylation controlled J (MCJ) protein, an indication of poor response to individual treatments for ovarian, breast, and other cancers.
Test offers early detection of metastatic melanomas & other cancers	Bosenberg	262	Non-invasive blood & tissue test, 1000-fold more sensitive than other methods, detects metastatic cancer at an early & treatable stage.
Electrostatic system provides accurate, reproducible exposure of cell cultures to aerosol particles	Petrucci	254	An electrostatic exposure chamber with flow controls deposits aerosol particules on cell cultures with 100 percent efficiency and no measurable damage.
Discrete-time analytic signal generation system	Mirchandani Effataoui	162	Redesigned Hilbert transformer offers truer SSB signal and decimates with less aliasing, better reconstruction, smaller-size data, and reduced power and memory requirements.
Reducing the cost of ERS standard calculation for EM-MS	Clougherty	218	For identification of chemicals at remediation sites and in explosives, direct calculation method facilitates the use of electron monochromators with mass spectrometers by providing a library of ER spectra standards.
Adaptive protective covering for a conductor	Huston Esser	181	Self-healing covering for electrical conductors toughens in areas exposed to wear and moisture, yet leaves the remaining cable flexible.
Antioxidant prevents organ damage from contrast agents	Meyer	258	Simultaneous administration of NAC with a contrast agent simplifies patient care while preventing or reducing organ damage.
Use of inhibitors of PACAP receptor activity for treatment of overactive bladder & pelvic floor pain syndrome	Vizzard Zvara	123	Inhibition of PACAP receptor activity may be the basis for the first effective treatment for pelvic floor pain & overactive bladder.
Anti-fungal agents & assay	Johnson	126	Development of effective treatment for fungal infections may be based on several small molecules that inhibit the budded-to-hyphal transition required for pathogenicity.
Inhibitors of transitions & biofilms cause yeast cells to lose virulence	Johnson	176	Small molecules may be used to treat yeast infections and added to medical supplies to prevent biofilm formation.
Emergence of a R-Type Ca2+ channel contributes to cerebral artery constriction following subarachnoid hemorrhage	Wellman	188	Unique peptide may reverse subarachnoid hemorrhage-induced vasospasm.
Therapeutic treatment of oxidative stress	Janssen-Heininger	284	Method for monitoring oxidative stress levels in the clinical diagnosis & management of major diseases.
Regulation of GSK3ß activity may offer disease treatments	Rincon	335	Abnormal levels of GSK3ß activity have been associated with a wide range of diseases, including neurological conditions, diabetes, & cancer. Effective treatments for these diseases may be based on the newly-discovered ability of p38 mitogen-activated protein kinase (MAPK) to phosphorylate GSK3ß activity.
Aqueous solvent facilitates Drosophila toxicology assays	Rand	355	Rapid toxicology assay using Drosphila embryos can avert the ethical concerns & high costs associated with mammalian models. Non-toxic, aqueous solvent dissolves the waxy layer of the Drosophila embryo shell, allowing a suspected toxic agent or bioactive compound to contact developing embryonic cells
Secreted factors from stem cells protect against tissue injury	Spees	356	Treatment may protect cardiac & cerebral tissues from damage through oxygen or nutrient deprivation. Defined populations of multipotent stromal cells are expanded in culture. If injected within 24 hours, the cells release biologically active agents that can rescue almost 50 percent of ischemic tissue & prevent damage to surrounding tissues.