UVM Innovations - All Technologies

Title	Inventors (Sort Names)	Case # (Sort #s)	Description	Podcasts
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Title	Inventors	Case #	Description
Sound processing improves audibility of music/speech in fMRI	Mantegna Naylor	404	Acoustic analysis and equalization mitigate fRMI noise without requiring special hardware.
Aeroacoustic cleaner removes dust from delicate surfaces	Marshall	396	A dust removal device combines acoustic levitation with aerodynamic flow to clean delicate surfaces without touching them.
Ultraviolet viewer offers portable detection of invisible flames	Huston McLean	395	Portable, fiber-optic viewer improves industrial and military safety by detecting the size and location of invisible flames without requiring power or a camera.
Ultrafine particle detectors allows in-situ engine exhaust monitoring	Frolik Holmen Barrett	389/402	Inexpensive detectors allow on-board monitoring of ultrafine exhaust particles that adversely affect human health. One configuration (389) also offers chemical analysis; a second configuration (402) offers greater portability and lower power requirements.
Whey-based wood adhesive offers environmental benefits	Guo	371	Wood glue incorporates whey, a sustainable biomass resource. The product meets or exceeds strength and durability standards for structural use.
High-intensity ultrasound improves scar ablation	Wu Langevin	370	Highly localized acoustic energy provides rapid scar ablation without the high recurrence rates and side effects of traditional treatments.
Blood test offers early risk assessment for heart attack	Mann	317	Blood plasma assay for patients with stable coronary artery disease determines risk of developing acute coronary syndrome.
Small, multipurpose transducer is stable and responsive	Gianetti	274	Small transducer with high signal output can be adapted to numerous research applications that require measurement of 0-10 gram forces.
Wastewater treatment system offers effective, low-cost phosphorus removal	Drizo	252	An inexpensive wastewater treatment system removes up to 95 percent of phosphorus from effluent.
Dairy by-product makes fungal pest management cost-effective	Costa	250	Sweet whey makes fungal control of environmental pests cost-effective by increasing the number of spores as much as 100-fold.
Genetic approach prevents mastitis, animal agriculture's most costly disease	Bramley Plaut Kerr	97	Transgenic cows that secrete lysostaphin are highly resistant to mastitis, while traditional approaches have yielded less than 15 percent success rates.
Microscopy system performs real-time particulate analysis	Yang	296	Microscopy system, based on a proprietary central core unit, detects, identifies, and characterizes particulate matter in real time.
Snowpack monitoring system improves water resource planning	Skalka Frolik	366	Snowpack monitoring system uses small, wireless sensors and offers high spatial and temporal resolution, low cost, and resistance to local influences.
Mobile app supports expert avalanche risk assessment	Skalka	367	The Stabilitron, a software tool for mobile devices, brings expert-level avalanche decision support to researchers and recreational users.
Noninvasive pulmonary airway resistance measurement system	Bates	168	Unrestrained video-assisted plethysmography provides high-throughput, non-destructive monitoring of airway resistance changes in mice.
Perineal massager eases childbirth anxiety	Young	288	Perineal massage in late-stage pregnancy can relieve anxiety & reduce the need for episiotomies & Caesarian deliveries. However, the technique is difficult & often performed incorrectly. Unique device for maternal self-care is simple to use & inexpensive to manufacture.
Disposable fiber optic TIR launching system	Kennedy Warshaw	210	Disposable TIRFM slide eliminates the need for costly optics and can be used on virtually any microscope.
Immunoassays achieve highest level of sensitivity to blood FVIII levels	Parhami-Seren	192	Assay detects FVIII concentrations significantly below 1% normal physiological concentration & can quantify FVIII in healthy individuals, hemophilia patients, & patients with anti-coagulant antibodies in whom APTT cannot be used.
Methods for determining notch signaling & uses thereof	Wesley	219	Notch signaling measurement method can be used to develop reagents or kits for basic research, diagnostics, & screening of potential therapeutics.
Embryonic stem cells protect & treat heart patients	Singla	253	Cell death and tissue scarring are major factors in the impairment of cardiac function associated with myocardial infarction. Now this damage can be reduced or prevented through implantation of embryonic stem cells in the heart tissue.
Diagnostic tool detects glutathionylated proteins	Janssen-Heininger	231	Method for detection of glutathionylated proteins determines their spatial location & concentration in intact cells & tissues. This may be used as a diagnostic tool or to evaluate the effectiveness of NO-delivery strategies.
Monoclonal antibodies for MCJ detection	Rincon	257	Three monoclonal antibodies detect the loss of expression of the methylation controlled J (MCJ) protein, an indication of poor response to individual treatments for ovarian, breast, and other cancers.
Test offers early detection of metastatic melanomas & other cancers	Bosenberg	262	Non-invasive blood & tissue test, 1000-fold more sensitive than other methods, detects metastatic cancer at an early & treatable stage.
Immunoassay for the quantitation of anti-factor VIII antibodies in human plasma	Mann	347	?
Electrostatic system provides accurate, reproducible exposure of cell cultures to aerosol particles	Petrucci	254	An electrostatic exposure chamber with flow controls deposits aerosol particules on cell cultures with 100 percent efficiency and no measurable damage.
Adhesive tape offers simple microbe detection	Giordano Gouli	260	An adhesive tape-based system retrieves even the most strongly held microbial particles without damaging delicate surfaces, allowing complete estimation of substrata contamination.
Automated fringe counting and property calculation system for bulge tester	Huston Sontag Sauter	69	Computer-based system allows manufacturers to automatically determine the material properties of thin films and provides high levels of convenience and control.
Thermoelectric device having an energy storage device located between its hot and cold sides	Huston Esser Plumpton	125	Parallel plate capacitors used as thermal insulators between the hot and cold sides of a thermoelectric device offer simple fabrication and increased thermal efficiency.
On-off magnetic attachment device	Huston Esser Plumpton	156	A rotating cylindrical dipole magnet serves as an on-off magnetic attachment device without requiring the power of an electromagnet and can provide four levels of energy and sliding/gripping action.
Discrete-time analytic signal generation system	Mirchandani Effataoui	162	Redesigned Hilbert transformer offers truer SSB signal and decimates with less aliasing, better reconstruction, smaller-size data, and reduced power and memory requirements.
System and method for analyzing the response of a mechanical system	Frolik	83	The response of a mechanical system to one or more inputs can be monitored in situ through several operatively coupled accelerometers that collect the data and feed it into signal processing software.
Facilitating multi-task run-time code for remote devices	Lee Sadjadi Wang	251	AKBRA provides a multistage methodology for implementing multi-task runtime code flexibly and quickly. Applications include surveillance devices, tele-medicine, stock trading, and traffic control.
Algorithm improves sampling of continuous data streams	Lee Al-Kateb Wang	256	Algorithm ensures uniformity in sampling continuous data streams when the sample size adapts to changes in the amount of available storage space.
Reducing the cost of ERS standard calculation for EM-MS	Clougherty	218	For identification of chemicals at remediation sites and in explosives, direct calculation method facilitates the use of electron monochromators with mass spectrometers by providing a library of ER spectra standards.
Advanced data mining tool queries multiple databases	Wu	269	Algorithm finds, analyzes, and develops rules for data patterns as queries of multiple databases proceed, resulting in faster queries and more comprehensive results.
Traffic volume forecasting tool simulates human memory	Sadek Huang	349	Data modeling tool for traffic volume forecasting applies several features of human memory to artificial intelligence. It offers greater speed and accuracy than other approaches while having low computational and storage requirements.
Adaptive protective covering for a conductor	Huston Esser	181	Self-healing covering for electrical conductors toughens in areas exposed to wear and moisture, yet leaves the remaining cable flexible.
Process for fabricating thin films and thin wire-like structures	Hendrick	144	Single-step, low-temperature process for fabricating thin films and thin wire-like structures, including organic semiconductor materials, offers a high degree of control and wide variation in materials and structures.
Active vibration damping for circuit boards	Huston Esser Plumpton	102	Electronic circuit boards exposed to severe shock and vibration are protected by active mass dampers that move out of phase with the vibrations and offer reduced weight compared to passive systems.
Thermoelectric device having an energy storage device located between its hot and cold sides	Huston Esser Plumpton	125	Parallel plate capacitors used as thermal insulators between the hot and cold sides of a thermoelectric device offer simple fabrication and increased thermal efficiency.
Integrated mems-based antivibration device	Huston Esser Plumpton	999	ON HOLD
Plasma enhanced cvd process for rapidly growing semiconductor films	Varhue	34	Silicon production process significantly reduces production temperature while dramatically increasing growth rate.
Process for fabricating thin films and thin wire-like structures	Hendrick	144	Single-step, low-temperature process for fabricating thin films and thin wire-like structures, including organic semiconductor materials, offers a high degree of control and wide variation in materials and structures.
Structure and method for abrupt pn junction diode formed using chemical vapor deposition processing	Varhue	36	Process for forming a semiconductor pn junction allows the original wafer surface to be contained within the depletion region and permits the diodes to be fabricated at any doping concentration.
Hybrid design knee joint prosthesis	Beynnon Incavo	174	Hybrid design for knee prostheses offers improved long-term stability through larger surface area for cement and undersurface area for bone ingrowth.
Knee joint prosthesis with a femoral component which links the tibiofermoral axis with the patellofemoral axis of rotation	Beynnon Incavo Coughlin	143	Kinematic studies of cadaver knee specimens can be used to develop an optimal femoral epicondylar axis for prostheses, providing a more normal range of motion.
Effective, low-risk approach to weight loss or gain	Galbraith	195	Intracranial administration of low-dose CoPP to inhibit NOS activity can promote weight loss while offering lower risk than gastric bypass surgery and circumventing the side effects of systemic NOS inhibition.
Depth sensor improves efficacy of cardiac ablation	Spector	302	Catheter-mounted sensor enables cardiologists to accurately determine lesion depth during cardiac ablation.
Antioxidant prevents organ damage from contrast agents	Meyer	258	Simultaneous administration of NAC with a contrast agent simplifies patient care while preventing or reducing organ damage.
Toxoplasma gondii apical membrane antigen-1	Ward	74	High-throughput screening method identifies compounds that inhibit the ability of Toxoplasa to infect mammalian cells. This may lead to development of chemotherapies & vaccines for toxoplasmosis, a common parasitic disease in humans & animals.
Inhibitors of API	Ward	86	?
Identification of anti-protozoal agents	Ward	90	Library of non-toxic infection inhibitors may be effective against a broad specturm of protozoa. Additional inhibitors may be discovered through assay system that measures ability of parasites to invade cells.
Use of inhibitors of PACAP receptor activity for treatment of overactive bladder & pelvic floor pain syndrome	Vizzard Zvara	123	Inhibition of PACAP receptor activity may be the basis for the first effective treatment for pelvic floor pain & overactive bladder.
Anti-fungal agents & assay	Johnson	126	Development of effective treatment for fungal infections may be based on several small molecules that inhibit the budded-to-hyphal transition required for pathogenicity.
Small molecules inhibit yeast-to-hyphal transition	Johnson	176	?
Emergence of a R-Type Ca2+ channel contributes to cerebral artery constriction following subarachnoid hemorrhage	Wellman	188	Unique peptide may reverse subarachnoid hemorrhage-induced vasospasm.
Methods & compositions for treating toxoplasma	Matrajt	193	Heat shock protein of Toxoplasma prevents the conversion pathway of cysts from bradyzoite to tachyzoite. This may lead to an effective treatment for toxoplasmosis & enable screening for additional inhibitors.
Molecules offer potential therapy for advanced melanoma	Bosenberg	236	Malignant melanoma patients may realize a significant survival benefit from intravenous delivery or gene therapy with two newly identified small molecules. These yielded greater than four-fold reduction of tumor size in mouse xenograft studies.
Therapeutic treatment of oxidative stress	Janssen-Heininger	284	Method for monitoring oxidative stress levels in the clinical diagnosis & management of major diseases.
Drug combination acts synergistically on cancer cells	Littenberg	309	Combination therapy dramatically increases kill rate in cancer cell cultures compared to either drug alone. Potentially effective in a wide range of cancerous and precancerous conditions, including breast, ovarian, prostate, and lung cancer.
Preventing obesity through regulation of a neural chemical	May	311	Stress-related biochemical process in the sympathetic nervous system may be a significant factor in the development of obesity. In addition, compounds that block or regulate this process may offer a safe & effective treatment of the condition.
Regulation of GSK3ß activity may offer disease treatments	Rincon	335	Abnormal levels of GSK3ß activity have been associated with a wide range of diseases, including neurological conditions, diabetes, & cancer. Effective treatments for these diseases may be based on the newly-discovered ability of p38 mitogen-activated protein kinase (MAPK) to phosphorylate GSK3ß activity.
PACAP expression & signaling mediates stress-induced anxiety-like behavior	May	344	?
MorC	Mintz	350	?
Aqueous solvent facilitates Drosophila toxicology assays	Rand	355	Rapid toxicology assay using Drosphila embryos can avert the ethical concerns & high costs associated with mammalian models. Non-toxic, aqueous solvent dissolves the waxy layer of the Drosophila embryo shell, allowing a suspected toxic agent or bioactive compound to contact developing embryonic cells
Secreted factors from stem cells protect against tissue injury	Spees	356	Treatment may protect cardiac & cerebral tissues from damage through oxygen or nutrient deprivation. Defined populations of multipotent stromal cells are expanded in culture. If injected within 24 hours, the cells release biologically active agents that can rescue almost 50 percent of ischemic tissue & prevent damage to surrounding tissues.
Factors for the protection of prolonged myocardial ischemia (MI)	Spees	369	Pending