Biomedical / Diagnostics

Dignostic tools and methods developed at UVM facilitate early detection and treatment of diseases such as acute coronary syndrome, melanoma, and hemophilia.

Title	Inventors	Case #	Description	Podcasts
Blood test offers early risk assessment for heart attack	Mann	317	Blood plasma assay for patients with stable coronary artery disease determines risk of developing acute coronary syndrome.
Disposable fiber optic TIR launching system	Kennedy Warshaw	210	Disposable TIRFM slide eliminates the need for costly optics and can be used on virtually any microscope. (Also in R&D Tools)
Antioxidant prevents organ damage from contrast agents	Meyer	258	Simultaneous administration of NAC with a contrast agent simplifies patient care while preventing or reducing organ damage. (Also in Therapeutics)
Immunoassays achieve highest level of sensitivity to blood FVIII levels	Parhami-Seren	192	Assay detects FVIII concentrations significantly below 1% normal physiological concentration & can quantify FVIII in healthy individuals, hemophilia patients, & patients with anti-coagulant antibodies in whom APTT cannot be used. (Also in R&D Tools)
Methods for determining notch signaling & uses thereof	Wesley	219	Notch signaling measurement method can be used to develop reagents or kits for basic research, diagnostics, & screening of potential therapeutics. (Also in R&D Tools)
Diagnostic tool detects glutathionylated proteins	Janssen-Heininger	231	Method for detection of glutathionylated proteins determines their spatial location & concentration in intact cells & tissues. This may be used as a diagnostic tool or to evaluate the effectiveness of NO-delivery strategies. (Also in R&D Tools)
Monoclonal antibodies for MCJ detection	Rincon	257	Three monoclonal antibodies detect the loss of expression of the methylation controlled J (MCJ) protein, an indication of poor response to individual treatments for ovarian, breast, and other cancers.
Test offers early detection of metastatic melanomas & other cancers	Bosenberg	262	Non-invasive blood & tissue test, 1000-fold more sensitive than other methods, detects metastatic cancer at an early & treatable stage.
Immunoassay for the quantitation of anti-factor VIII antibodies in human plasma	Mann	347	?