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Depth sensor improves efficacy of cardiac ablation
Correct lesion depth is essential when cardiac ablation is used to treat arrhythmia. Now cardiologists can accurately judge lesion depth with a catheter-mounted sensor. Electrode pairs are mounted within the sensor and linked to a processor. The system measures signal amplitude, calculates differential values to determine signal attenuation, and provides accurate measurements of lesion depth as the procedure takes place. (more)
Labeling system improves tracking of syringe contents
Small quantities of blood products are often transfered from plastic bags to syringes. The smaller surface area of a syringe often remains unlabeled or poorly labeled, putting patients at risk. However, a new labeling system that connects to syringe barrels of varying diameters can accommodate ample identification data while remaining securely attached. (more)
Algorithm improves sampling of continuous data streams
Often storage capacity in sensor-based sampling devices is shared among multiple applications or data streams. When available storage increases due to a reduction in the number of applications or data streams, more samples can be collected. However, until now it has not been possible to ensure uniform sampling of continuous data if the sample size adapts to available storage space. A new algorithm corrects this deficiency by ensuring uniformity when the sample size changes. (more)
Advanced data mining tool queries multiple databases
Sequential queries of multiple databases can yield valuable information for business and research. However, this approach is time consuming and offen fails to recognize important patterns. A new algorithm that finds, analyzes, and develops rules for data patterns as the query proceeds is many times faster than sequential queries and produces more comprehensive results. (more)
Antioxidant prevents organ damage from contrast agents
The administration of N-Acetylcysteine (NAC) prior to radiographic procedures is known to protect many tissues and organs, including the kidneys, from the damage that may be caused by high-dose contrast agents. Now simultaneous administration of NAC with the contrast agent can simplify patient care while preventing or reducing organ damage. (more)
Test offers early detection of melanomas and other cancers
A new blood and tissue test can detect metastatic cancer at an early and treatable stage.
This noninvasive test, which analyzes specific genes for abnormalities in a chemical process called DNA methylation, detects over 95% of advanced melanomas. It is also up to 1,000-fold more sensitive than other testing methods, enabling it to detect very low levels of cancer. (more)
Perineal massager eases childbirth anxiety
Perineal massage in late-stage pregnancy can relieve anxiety and reduce the need for episiotomies and Caesarian deliveries. However, the technique is difficult and often performed incorrectly. A new device is simple to use, inexpensive to manufacture, and unique in the maternal self-care market. (more)
Drug combination acts synergistically on cancer cells
A novel combination therapy has been shown to dramatically increase the kill rate in cancer cell cultures compared to either drug alone. The combination is likely to be very well tolerated in clinical practice and is potentially effective in a wide range of cancerous and precancerous conditions, including breast, ovarian, prostate, and lung cancer. (more)
Molecules offer potential therapy for advanced melanoma
Although malignant melanoma patients are generally unresponsive to standard treatments, they may now realize a significant survival benefit from intravenous delivery or gene therapy with two newly identified small molecules. These secreted proteins have yielded greater than four-fold reduction of tumor size in mouse xenograft studies. (more)
Fast DNA assay determines fraction of active protein molecules
In studies of DNA binding proteins, affinity chromatography often results in a fraction of proteins being in a mis-folded (non-active) state. Now a rapid, accurate assay using a fluorescent reporter molecule can be used to meet the frequent need for exact quantification of active protein molecules. The assay can also be modified for use in complex DNA/protein experiments. (more)
Feeder-free culture method grows embryonic stem cells
Embryonic stem cells hold promise for transplantation medicine, in part due to their characteristics of self-renewal and pluripotency. However, contamination from infectious agents in feeder cells must be minimized. Now wnt3a has been identified as a factor that supports self-renewal and pluripotency in ES cells, offering an option as a feeder-free culture method. (more)
Monoclonal antibodies could determine individual response to chemotherapy
Current treatment of ovarian, breast, and other cancers does not include a test for individual drug response. However, three newly developed monoclonal antibodies can detect the loss of expression of the methylation controlled J (MCJ) protein, an indication of poor response. Use of these antibodies will help doctors determine the most promising treatments for individual cases, leading to better patient response and recovery. (more)
Adhesive tape offers simple, comprehensive microbe detection
Microbial particles have strong adhesive properties, and current surface sampling techniques may not retrieve or allow investigators to detect all types of contaminants. Now a simple, adhesive tape-based system, which retrieves even the most strongly held particles without damaging delicate surfaces, allows more complete and trustworthy estimation of contamination in the substrata. (more)
Dairy by-product makes fungal pest management cost-effective
Production costs and space requirements have limited the use of fungi for control of biological pests such as insects and weeds. However, sweet whey, a by-product of cheese-making, allows fungi applied in the environment to grow in tiny droplets. The resulting microfactories increase the number of spores by as much as 100-fold, reducing the cost of fungal pest control and increasing effectiveness through greater opportunity for fungus/pest contact. (more)
Reducing the cost of ERS standard calculation for EM-MS
The coupling of electron monochromators to mass spectrometers provides a potentially powerful tool for identification of chemicals at remediation sites and in explosives. However, a library of ER spectra standards is required to associate a spectrum with the molecule from which it arose. A new, direct calculation method can facilitate the use of EM-MS for risk assessment by reducing the cost of obtaining these standards. (more)
Facilitating multi-task run-time code for remote devices
Task-specific run-time code in remote devices has, until now, been cumbersome to change and unable to handle the variety of situations that might arise. AKBRA provides a multistage methodology for implementing multi-task operations flexibly and quickly. Applications include surveillance devices, tele-medicine, stock trading, and traffic control. (more)
Diagnostic tool detects glutathionylated proteins
A new method detects glutathionylated proteins and determines their spatial location and concentration in intact cells and tissues. This may be used as a diagnostic tool or to evaluate the effectiveness of NO-delivery strategies. (more)
Diagnostic tool detects nitrosylated proteins
A modified biotin switch method, using other chemical reagents, visualizes S-nitrosylated proteins and determines their spatial location and concentration in intact cells and tissues. Hospitals and research centers can use this method to determine functional NO. (more)
Immunoassays achieve highest level of sensitivity to blood FVIII levels
A new assay detects FVIII concentrations significantly below 1% normal physiological concentration, or 1 - 4,000 pM. It can quantify FVIII in healthy individuals, hemophilia patients, and patients with anti-coagulant antibiodies in whom APTT cannot be used. (more)
Effective, low-risk approach to weight loss or gain
Intracranial administration of low-dose CoPP to inhibit NOS activity can promote weight loss while offering lower risk than gastric bypass surgery and circumventing the side effects of systemic NOS inhibition. This approach could be altered to promote weight gain in those suffering from anorexia. (more)
Improving the accuracy of micrometastasis detection in blood and bone marrow
The use of cytokeration antibodies derived from different species or different isotypes of the same species enables clinicians to identify falsely stained cells and verify true micrometastasis in blood or bone marrow. This method could be used to enhance commercial staining/detection kits. (more)
Electrostatic system quantitatively, accurately, and reproducibly exposes cell cultures to areosol particles
An electrostatic exposure chamber with flow controls deposits aerosol particles on cell cultures with 100% efficiency and no measurable damage. With no accepted commercial method currently available, this invention represents a major advancement in the fields of environmental pathology, pollution toxicity, environmental monitoring, air quality, and emission controls. (more)
Therapeutic agent for streptococcus circumvents antibiotic resistance
A newly isolated phage-associated lysin offers low incidence of antibiotic resistance in the treatment of human and animal strep-based infections. The lysin can also be used for the detection of affected bacteria. (more)
TIRFM system features rapid, accurate autofocus and quality confirmation
A unique TIRFM focus feedback system uses the return TIR beam as a signal source. This signal can be used to drive a highly accurate autofocusing system and confirm the existence of TIR. (more)
Acanthamoeba offers versatile, low-cost alternative
to other
recombinant protein expression systems
The use of Acanthamoeba castellanii allows low-cost expression of proteins that are not well expressed in current systems. In addition, Acanthamoeba is simple to grow, easily lysed, and produces stable cell lines that can be stored at room temperature. (more)
Genetic approach prevents mastitis, animal agriculture's
most costly disease
Transgenic cows that secrete lysostaphin have been shown to be highly resistant to mastitis, a disease that costs the U.S. dairy industry approximately $2 billion per year. Traditional approaches such as vaccination and sterilization have yielded less than a 15 percent success rate. (more)
Disposable TIRFM slide reduces cost
The imaging advantages of TIRFM may be offset by the high costs of the objective lenses and other optics required for it. A disposable TIRFM slide, utilizing laser light guided by fiber optics, offers an inexpensive alternative that can be used on virtually any microscope with little or no modification.(more)
Cyclophosphazene photoresist material offers superior hardness, resolution, and thermal properties
A photoresist material that incorporates a cyclophosphazene monomer offers significant advantages over known alternatives: It prevents thermal degradation; produces a hard, thin film; and accepts high resolution patterns when etched. (more)
Analyzing mechanical system responses in situ
A data collection and analysis system offers in situ monitoring of mechanical system outputs in response to a variety of inputs. This can be used for determination of system performance and maintenance requirements, calibration, and simulation. Wireless data transmission can also be configured into the monitoring system. (more)
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